Results
| PMID | 16055459 |
| Gene Name | ADIPOQ |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 78 |
| Population details | 78 (48 women with endometriosis, 30 women without endometriosis) |
| Sex | Female |
| Associated genes | Adiponectin |
| Other associated phenotypes |
Endometriosis |
|
Hum Reprod. 2005 Dec;20(12):3510-3. Epub 2005 Jul 29. Takemura, Yuri| Osuga, Yutaka| Harada, Miyuki| Hirata, Tetsuya| Koga, Kaori| Morimoto, Chieko| Hirota, Yasushi| Yoshino, Osamu| Yano, Tetsu| Taketani, Yuji Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Tokyo, 113-8655, Japan. BACKGROUND: Adiponectin is a pleiotropic cytokine originally discovered as an adipocyte-specific gene product. Serum adiponectin concentrations have been reported to be low in women with endometrial cancer, breast cancer and uterine leiomyoma, suggesting possible involvement of adiponectin in these estrogen-related diseases. We thus addressed the relevance of adiponectin to endometriosis, an estrogen-dependent disease, in the present study. METHODS: Women with (n = 48) and without (n = 30) endometriosis undergoing laparoscopy were recruited in this study. Blood samples were collected, and serum adiponectin concentrations were measured using a specific enzyme-linked immunosorbent assay. The relationship between laparoscopic findings and serum adiponectin concentrations was analysed. RESULTS: The adiponectin concentrations in the serum of the women with endometriosis (median, 13.1 microg/ml; interquartile range, 10.2 - 16.7) were significantly lower than those of the women without endometriosis (15.9 microg/ml, 13.5 - 19.5; P = 0.008). A significant negative correlation was found between serum adiponectin concentrations and both endometriosis scores (R = - 0.307, P = 0.006) and adhesion scores (R = - 0.254, P = 0.026) of the revised American Society for Reproductive Medicine classification of endometriosis. CONCLUSIONS: The present findings suggest that adiponectin is implicated in the pathophysiology of endometriosis. Mesh Terms: Adiponectin/*blood/genetics| Adult| Case-Control Studies| Endometriosis/*blood/*physiopathology| Enzyme-Linked Immunosorbent Assay| Female| *Gene Expression Regulation| Humans| Laparoscopy| Models, Statistical|DA 2006/03/17 09:00 |
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